胡亮研究员

胡亮研究员

上海市特聘教授、上海市中医药大学中西医结合学院心血管研究中心主任、上海市活血化瘀专委会委员、中国医师协会上海市心血管分会委员、医学会心血管病学分会委员

主要研究方向：血小板异常活化和心肌梗死发病机制；传统中药抗血小板在心血管疾病中的治疗机制；抗血小板药物筛选和药效学研究

Chen Y*, Fu W*, Zheng Y, Yang J, Liu Y, Qi Z, Wu M, Fan Z, Yin K, Chen Y, Gao W, Ding Z, Dong J, Li Q#, Zhang S#, Hu L#. Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. Eur Heart J. 2022 Feb 15:ehac034. doi: 10.1093/eurheartj/ehac034. Epub ahead of print. PMID: 35165707. (IF：29.9)

Zhang S*#, Liu Y*, Wang X*, Yang L*, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y#, Hu L#. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol. 2020 Sep 4;13(1):120. doi: 10.1186/s13045-020-00954-7. PMID: 32887634; PMCID: PMC7471641. (IF：17.4)

Zhou Y*, Hu L*, Tang W*, Li D, Ma L, Liu H, Zhang S, Zhang X, Dong L, Shen X, Chen S, Xue R, Zhang S. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol. 2021 Jan 7;14(1):9. doi: 10.1186/s13045-020-01028-4. PMID: 33413510; PMCID: PMC7791875. (IF：17.4)

Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z and Ge J. PCSK9 Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36. Circulation. 2020. （IF：29.5）

Hu L, Chang L, Zhang Y, Zhai L, Zhang S, Qi Z, Yan H, Yan Y, Luo X, Zhang S, Wang Y, Kunapuli SP, Ye H, Ding Z#. Platelets express activated p2y12 receptor in patients with diabetes. Circulation. 2017 (IF: 29.5)

Zhang S, Zhang SH, Hu L, Zhai L, Xue R, Ye J, Chen L, Mruk J, Cheng G, Kunapuli SP, Ding Z#. Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis. Circulation 2015; 131(13): 1160 - 1170 (Featured work with an editorial；IF: 29.5)

Hu L, Fan Z, Du H, Ni R, Zhang S, Yin K, Ye J, Zhang Y, Wei X, Zhang X, Gross PL, Kunapuli SP, Ding Z#. BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thromb Haemost 2011; 106(6): 1204 - 1214 (IF: 5.4)